A 2-year-old boy with a testicular mass. Diagnosis: testicular tumor of adrenogenital syndrome due to 11-beta-hydroxylase deficiency.
نویسندگان
چکیده
androsterone sulfate (DHEAS), 17-OH progesterone levels, and ultrasonographic fi ndings consistent with bilateral testicular mass, Leydig cell tumor (LCT) had been considered. Bilateral orchiectomy had been offered in another tertiary medical center. His clinical history revealed a normal delivery at 37th gestational week, with a birth weight of 2,750 g, more remarkable weight and height gain compared with his peers since birth, presence of acne for 1 year, and normal motor-mental development, except delay in Tolga Unuvar, MD, is Assistant Professor; Korcan Demir, MD, is Resident Fellow; Ayhan Abaci, MD, is Assistant Professor; Ali Atas, MD is Assistant Professor; and Ece Bober, MD is Professor, Department of Pediatric Endocrinology, Faculty of Medicine, Dokuz Eylul University, Izmir, Turkey. Handan Cakmakci, MD, is Professor, Department of Radiology, Faculty of Medicine, Dokuz Eylul University. Address correspondence to: Prof. Dr. Ece Bober, Department of Pediatric Endocrinology, Faculty of Medicine, Dokuz Eylul University, İzmir, Turkey; or e-mail [email protected]. Dr. Unuvar; Dr. Demir; Dr. Abaci; Dr. Atas; Dr. Cakmakci; and Dr. Bober have disclosed no relevant fi nancial relationships. doi: 10.3928/00904481-20100726-04 Figure 1. Initial scrotal ultrasound examination revealed (a) two nodular mass lesions (arrows) within the left testis and (b) one mass lesion within the right testis (arrows).
منابع مشابه
A Case of Bilateral Testicular Tumors Subsequently Diagnosed as Congenital Adrenal Hyperplasia Due to 21-Hydroxylase Deficiency
21-hydroxylase deficiency (21-OHD) caused congenital adrenal hyperplasia (CAH) is a group of autosomal recessive genetic disorders resulting from mutations in genes involved with cortisol (CO) synthesis in the adrenal glands. Testicular adrenal rest tumors (TARTs) are rarely the presenting symptoms of CAH. Here, we describe a case of simple virilizing CAH with TARTs, in a 15-year-old boy. The p...
متن کاملMetachronous Bilateral Testicular Leydig-Like Tumors Leading to the Diagnosis of Congenital Adrenal Hyperplasia (Adrenogenital Syndrome)
A 33-year-old male with a history of left testis Leydig cell tumor (LCT), 3-month status after left radical orchiectomy, presented with a rapidly enlarging (0.6 cm to 3.7 cm) right testicular mass. He underwent a right radical orchiectomy, sections interpreted as showing a similar Leydig cell-like oncocytic proliferation, with a differential diagnosis including metachronous bilateral LCT and me...
متن کاملTesticular Adrenal Rest Tumor in 11-Beta-Hydroxylase Deficiency Driven Congenital Adrenal Hyperplasia
Testicular adrenal rest tumors (TART) occur often as asymptomatic nodules in corticotropin-dependent lesions aberrant adrenal tissue in congenital adrenal hyperplasia (CAH) patients. The present manuscript is about an unusual case of a 16-year-old CAH patient due to 11β-hydroxylase deficiency. He underwent testicle biopsy because of testicle tumor suspicion and diagnosed with TART.
متن کاملSELF ASSESSMENT ANSWERS Testicular mass in a resting cell
An adrenal cortical cell rest, an interstitial cell, and a pleuripotent cell have all been suggested as the origin of testicular masses in congenital adrenogenital syndrome. 2 Embryologically the development of the adrenal gland and the genital ridge occurs in close proximity. Adrenal cell rests are therefore known to occur in the spermatic cord, testis, broad ligament, and the ovary. The norma...
متن کاملSELF ASSESSMENT ANSWERS Testicular mass in a resting cell
An adrenal cortical cell rest, an interstitial cell, and a pleuripotent cell have all been suggested as the origin of testicular masses in congenital adrenogenital syndrome. 2 Embryologically the development of the adrenal gland and the genital ridge occurs in close proximity. Adrenal cell rests are therefore known to occur in the spermatic cord, testis, broad ligament, and the ovary. The norma...
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ورودعنوان ژورنال:
- Pediatric annals
دوره 39 8 شماره
صفحات -
تاریخ انتشار 2010